You can automatically sign your Python wheel packages before submitting them to PyPi.

In order to do this, you will first need to install wheel:

$ sudo pip install wheel

After that, generate a key:

$ wheel keygen

Now, to manually sign a package, type:

$ wheel sign dist/package-name-and-version.whl

You can also check the signature by executing:

$ wheel verify dist/package-name-and-version.whl

You can also sign the packages automatically upon execution of python setup.py bdist_wheel.

In order to do this, edit your ~/.bash_profile file and add the following line:

export WHEEL_TOOL=/usr/local/bin/wheel

You can then reload your configuration with source ~/.bash_profile and you're ready to go.

Happy wheeling!